Genomic instability

Co-directional replication–transcription conflicts lead to replication restart

Microbiology / Molecular Biology / DNA replication / Multidisciplinary / Nature / ribosomal RNA / Bacillus subtilis / Genomic instability / Multienzyme complexes / DNA binding proteins / ribosomal RNA / Bacillus subtilis / Genomic instability / Multienzyme complexes / DNA binding proteins

Array-comparative genomic hybridization of central chondrosarcoma

Cancer / Humans / Female / Nucleic acid hybridization / Male / Prognosis / Genomic instability / Ribosomal Protein / Array Comparative Genomic Hybridization / Prognosis / Genomic instability / Ribosomal Protein / Array Comparative Genomic Hybridization

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

DNA repair / Multidisciplinary / Sequence Analysis / Neural Development / Medulloblastoma / Mice / Animals / Genome Analysis / Spectrum / Genomic instability / Homologous Recombination / DNA binding proteins / Mice / Animals / Genome Analysis / Spectrum / Genomic instability / Homologous Recombination / DNA binding proteins

Ambient Oxygen Promotes Tumorigenesis

Multidisciplinary / Western blotting / Mice / Female / Animals / Carcinogens / PLoS one / Tumor Suppressor Gene / Oxygen / Genomic instability / Base Sequence / Oxidative Dna Damage / Survival Time / Skin Neoplasms / Carcinogens / PLoS one / Tumor Suppressor Gene / Oxygen / Genomic instability / Base Sequence / Oxidative Dna Damage / Survival Time / Skin Neoplasms

BRCA1 DEFICIENCY EXACERBATES ESTROGEN INDUCED DNA DAMAGE AND GENOMIC INSTABILITY

Cancer / DNA repair / Humans / Female / Breast / Estrogens / Genomic instability / Estradiol / Estrogens / Genomic instability / Estradiol

Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice

Biological Sciences / Brain / Mitochondrial DNA / Humans / Mice / Animals / Human Molecular Genetics / Genomic instability / Animals / Human Molecular Genetics / Genomic instability

Co-directional replication–transcription conflicts lead to replication restart

DNA replication / Multidisciplinary / Nature / ribosomal RNA / Bacillus subtilis / Genomic instability / Multienzyme complexes / DNA binding proteins / Genomic instability / Multienzyme complexes / DNA binding proteins

MAPEO DE LAS REGIONES COMUNES DE DELECIÓN EN 5P15 EN CARCINOMA CERVICAL Y SU OCURRENCIA EN LESIONES PRECANCEROSAS

Genetics / Tumor Suppressor Gene / Genomic instability / Genetic distance / Cervical Intraepithelial Neoplasia

A transgenic mouse model for mammary carcinogenesis

Breast Cancer / Gene expression / Disease susceptibility / Transgenic Mice / Mutation / Mice / Female / Animals / Oncogene / Carcinogens / Clinical Sciences / Mouse Model / Mammary gland / Model System / Flow analysis / Genomic instability / Amino Acid Profile / Cell Proliferation / Transgenic Mouse Technology / Transgene Expression / Mice / Female / Animals / Oncogene / Carcinogens / Clinical Sciences / Mouse Model / Mammary gland / Model System / Flow analysis / Genomic instability / Amino Acid Profile / Cell Proliferation / Transgenic Mouse Technology / Transgene Expression

Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer

Genetics / Oxidative Stress / DNA damage / Colorectal cancer / Mitochondrial DNA / Humans / Mutagenesis / Glucose / Glucose Metabolism / Reactive Oxygen Species / Female / Male / Glycolysis / Mitochondrial Genome / Aged / Middle Aged / Oxidative Damage / Oxidative phosphorylation / Experimental Tests / Genomic instability / PLoS Genetics / Humans / Mutagenesis / Glucose / Glucose Metabolism / Reactive Oxygen Species / Female / Male / Glycolysis / Mitochondrial Genome / Aged / Middle Aged / Oxidative Damage / Oxidative phosphorylation / Experimental Tests / Genomic instability / PLoS Genetics

p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes

DNA replication / DNA damage / Biological Sciences / Humans / Histones / Genomic instability / Cell cycle checkpoints / Melanocytes / Cell Proliferation / retinoblastoma protein (RB1). / Genomic instability / Cell cycle checkpoints / Melanocytes / Cell Proliferation / retinoblastoma protein (RB1).

Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice

Biological Sciences / Brain / Mitochondrial DNA / Humans / Mice / Animals / Human Molecular Genetics / Genomic instability / Animals / Human Molecular Genetics / Genomic instability

BRCA1 Deficiency Exacerbates Estrogen Induced Dna Damage and Genomic Instability

Cancer / DNA repair / Humans / Female / Breast / Estrogens / Genomic instability / Estradiol / Estrogens / Genomic instability / Estradiol

Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice

Biological Sciences / Brain / Mitochondrial DNA / Humans / Mice / Animals / Human Molecular Genetics / Genomic instability / Animals / Human Molecular Genetics / Genomic instability

Cancer genetics: colorectal cancer as a model

Genetics / Genetic Epidemiology / Human Genetics / Genomics / Population Genetics / Molecular Genetics / Epigenetics / Low Frequency / Cytogenetics / Humans / Methylation / Pharmacogenetics / Clinical Genetics / Clinical Sciences / Human Genome / Genomic instability / Genetic variation / Adenoma / Cumulant / Colorectal Neoplasms / Molecular Genetics / Epigenetics / Low Frequency / Cytogenetics / Humans / Methylation / Pharmacogenetics / Clinical Genetics / Clinical Sciences / Human Genome / Genomic instability / Genetic variation / Adenoma / Cumulant / Colorectal Neoplasms

BRCA1 Deficiency Exacerbates Estrogen Induced Dna Damage and Genomic Instability

Cancer / DNA repair / Humans / Female / Breast / Estrogens / Genomic instability / Estradiol / Estrogens / Genomic instability / Estradiol

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